Broad Institute Genomic Services offers a comprehensive set of solutions for clinical trial sequencing. From choosing and validating the appropriate technology and study design, through sample receipt and processing, to data generation and analysis, we work together every step of the way to ensure that data produced provide the pharmacogenomic insight to drive therapeutic efficacy.
All clinical trial sequencing is performed under a quality system by our Clinical Research Sequencing Platform, which assures the highest degree of reliability and verifiability. Our laboratory informatics system provides end-to-end process tracking, secure data storage, and an audit trail suitable for clinical use.
Our Clinical Research Sequencing Platform has experience performing end-to-end genomic analysis, from sample preparation through data analysis, for clinical trials through Phase III. In addition to Whole Exome Sequencing with Germline or Somatic Analysis and a Broad-developed cancer panel, we offer the ability to create custom assays for clinical trials.
Leveraging our extensive experience in NGS library preparation and data analysis, we offer the ability to rapidly design, validate and implement custom content panels for clinical trial use. We have experience implementing custom panels that deliver validated high sensitivity, specificity, accuracy, and precision, combined with end-to-end process tracking, secure data storage, and an audit trail.
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The application of next generation sequencing in a clinical laboratory setting is a new endeavor. As part of the Broad Institute’s efforts to facilitate translational genomics, the Clinical Research Sequencing Platform (CRSP) was created in October 2013.